Manhattan and Q‐Q plots for sensation seeking, alcohol consumption, and AUD GWAS are shown in Figure 2. In the sensation seeking GWAS (N^ = 710,971; ζ g = 0.087, SE = 0.003), 1092 independent GWS variants, mapped to 262 independent genomic loci, were identified (Tables S7 and S8). Thirty‐one genomic loci (~12%) represented novel loci that were not (A) associated with or in LD (r 2 > .1) with SNPs associated with any of the three sensation seeking indicator GWAS, (B) previously associated with any trait for studies included in the NHGRI‐EBI GWAS catalogue (version 104: 2021‐09‐15), 52 and (C) not identified in other recently conducted trait‐relevant GWAS (e.g., impulsive personality traits 53 and externalising behaviour 54 ; Table S9). However, 14 of these loci map to genes previously associated with these traits through positional mapping of independent loci or gene‐based tests (Table 2). The top association in the sensation seeking GWAS was an intronic CADM2 variant (rs2069123, P = 8.85 × 10−98) identified in prior GWAS of related traits. 21 , 22 , 53 , 54 The alcohol consumption
