gene‐based tests (Table 2). The top association in the sensation seeking GWAS was an intronic CADM2 variant (rs2069123, P = 8.85 × 10−98) identified in prior GWAS of related traits. 21 , 22 , 53 , 54 The alcohol consumption GWAS (N^ = 1,388,120; ζ g = 0.040, SE = 0.002) detected 842 independent GWS SNPs constituting 188 independent genomic loci (Tables S10 and S11). The top hit in this GWAS was an intergenic variant (rs138495951, P = 5.20 × 10−165) mapped to the alcohol metabolism gene ADH1B, replicating previous GWAS for alcohol traits. 19 , 23 , 28 The AUD GWAS meta‐analysis (n effective = 220,182; hg2 = 0.086, SE = 0.004; liability‐scale hg2 = 0.237, SE = 0.012) detected 65 independent GWS SNPs constituting 31 independent genomic loci (Tables S12 and 13). The top hit in this GWAS was also a common ADH1B variant (rs1229984, P = 5.99 × 10−107), again replicating prior studies. 27 , 28 Univariate LDSC results for all three GWAS and Q SNP summaries for sensation seeking and alcohol consumption are reported in Table S14 and bivariate LDSC results in Table S15.
