We also took advantage of LD differences across populations to fine-map association signals using Bayesian methods14,15. At 10 of 27 loci fine-mapped for BMI on Metabochip, the addition of non-European individuals into the meta-analysis either narrowed the genomic region containing the 99% credible set, or decreased the number of SNPs in the credible set (Supplementary Table 12 and Supplementary Fig. 10). At the SEC16B and FTO loci, the all ancestries credible set includes a single SNP, although the SNP we highlight at FTO (rs1558902) differs from that identified by a recent fine-mapping effort in African-American cohorts16. Fine-mapping efforts using larger, more diverse study samples and more complete catalogues of variants will help to further narrow association signals.
