distribution. The P-value reflects the significance of the observed overlap between the input gene list and the module's members as compared to random expectations. A small P-value indicates that more of the module's members are present in the input list than expected by chance. If, for example, the input list contains differentially expressed genes from a case–control study, overrepresentation analysis may point to pathways and functional sub-networks that are dysregulated in the disease state. Overrepresented modules are shown in downloadable lists sorted by the significance of over-representation (P-value) and modules of interest can be visualized in order to see the specific relations between their members.
