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Chunk #19 — RESULTS — UNIVERSITY OF WISCONSIN TRANSDISCIPLINARY TOBACCO USE RESEARCH CENTER (UW-TTURC)

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Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success.
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In this trial, 47.3% of participants were abstinent at end-of-treatment (8 weeks post-quit). In a simple logistic regression model, abstinence is predicted by treatment assignment (placebo versus active treatment) after adjusting for age and gender. Having any pharmacologic treatment, compared to the placebo group, increased abstinence by over 85% (OR=1.87, 95% CI=1.42-2.45, df=1, p=8.1×10−6). Smoking fewer cigarettes per day was the strongest predictor of abstinence (OR=0.67, 95% CI=0.60-0.75, p =3.3×10−11).