Chunk #69 — Methods — Differential chromatin accessibility analysis — Comparison of differentially accessible genes and differentially expressed genes

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Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder.

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To calculate the association between gene expression and chromatin accessibility differences for each gene, we assigned to each gene with at least 1 DAR (FDR < 0.2) in the promoter region the log2 fold change of the DAR with the highest ATAC signal, as well as the log2 fold change of the gene’s expression.