Chunk #21 — RESULTS — Previously reported CNVs in our genome-wide CNV analysis

Source

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.

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≤ 0.025 in the array-based replication analyses. CNVR 10q11.22 (1) (Table 2) covers four genes: (i) the pancreatic polypeptide receptor 1 (PPYR1) was a member of the seven transmembrane domain-G-protein-coupled receptor family and pancreatic polypeptide (PP) is a potent anti-obesity agent known to inhibit food intake (27), (ii) Synaptotagmin XV (SYT15), (iii) the G protein regulated inducer of neurite outgrowth 2 (GPRIN2) and (iv) the heterogeneous nuclear ribonucleoprotein A1 pseudogene (LOC728643).