A total of 273 SNPs from eight dopamine-related genes were individually tested for association with sensation seeking, controlling for demographic characteristics. Results for the individual-SNP association tests (for those SNPs whose regression weights met p<0.05) are reported in Table 2. Table S1 in the supporting information available on-line presents results from all 273 association tests. Twelve SNPs met significance criteria for association with sensation seeking, as defined by p < 0.05 and FDR < 0.10. By comparison, only three SNPs in the randomized genotype condition (rs2042449 and rs9312866 in SLC6A3, and rs1611114 in DBH) were significant by chance (at p < 0.05), and none of these passed FDR criteria (i.e. the p-value of the top-ranked SNP was greater than its FDR value). Because the number of SNPs meeting p < 0.05 was substantially greater in the correct genotype tests than in the tests using randomly assigned genotypes, and because all of the SNPs in the correct genotype condition met FDR criteria, compared to none of the SNPs in the random genotype condition, we concluded that the implicated SNPs are likely true associations with sensation seeking, at least in the current data set.
