Predicting sensation seeking from dopamine genes. A candidate-system approach.
paper
Primary
Public
- Authors
- Derringer, Jaime; Krueger, Robert F; Dick, Danielle M; Saccone, Scott; Grucza, Richard A; Agrawal, Arpana; Lin, Peng; Almasy, Laura; Edenberg, Howard J; Foroud, Tatiana; Nurnberger, John I; Hesselbrock, Victor M; Kramer, John R; Kuperman, Samuel; Porjesz, Bernice; Schuckit, Marc A; Bierut, Laura J; Gene Environment Association Studies (GENEVA) Consortium
- Year
- 2010
- Journal
- Psychological science
- PMID
- 20732903
- DOI
- 10.1177/0956797610380699
- PMCID
- PMC3031097
Sensation seeking is a heritable personality trait that has been reliably linked to behavioral disorders. The dopamine system has been hypothesized to contribute to variations in sensation seeking between different individuals, and both experimental and observational studies in humans and nonhuman animals provide evidence for the involvement of the dopamine system in sensation-seeking behavior. In this study, we took a candidate-system approach to genetic association analysis of sensation-seeking behavior. We analyzed single-nucleotide polymorphisms (SNPs) from a number of dopaminergic genes. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effect of SNPs that were significantly associated with sensation-seeking behavior. Multiple SNPs in four dopamine genes accounted for significant variance in sensation-seeking behavior between individuals. These results suggest that multiple SNPs, aggregated within genes that are relevant to a specific neurobiological system, form a genetic-risk score that may explain a significant proportion of observed variance in human traits such as sensation-seeking behavior.
No figures extracted from this document.
1–19 of 19
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood. | Vrantsidis DM et al. | — | 2023 | → |
| Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits. | Kassim FM | — | 2023 | → |
| Current biopsychosocial science on understanding kink. | Williams DJ et al. | — | 2022 | → |
| Dopamine increases risky choice while D2 blockade shortens decision time. | Hirschbichler ST et al. | — | 2022 | → |
| The dubious precision and utility of heritability estimates. | Heine SJ et al. | — | 2022 | → |
| When brain stimulation backfires: the effects of prefrontal cortex stimulation on impulsivity. | Bell SB et al. | — | 2022 | → |
| Dopaminergic Genetic Variation in Young Adolescents: Associations with Sensation-Seeking. | Sapuram VR et al. | — | 2021 | → |
| A Systematic Literature Review of the Association Between Somatic Symptom Disorder and Antisocial Personality Disorder. | Espiridion ED et al. | — | 2020 | → |
| Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score. | Treble-Barna A et al. | — | 2020 | → |
| Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior. | Saloner R et al. | — | 2020 | → |
| Neural activity moderates the association between sleep and risky driving behaviors in adolescence. | Baker AE et al. | — | 2020 | → |
| Threat or thrill? the neural mechanisms underlying the development of anxiety and risk taking in adolescence. | Baker AE et al. | — | 2020 | → |
| Gene set enrichment analysis to create polygenic scores: a developmental examination of aggression. | Elam KK et al. | — | 2019 | → |
| High sensation seeking is associated with behavioral and neural insensitivity to increased negative outcomes during decision-making under uncertainty. | Xu S et al. | — | 2019 | → |
| Simulation of model overfit in variance explained with genetic data | Derringer J | — | 2019 | — |
| Affiliation with substance-using peers: Examining gene-environment correlations among parent monitoring, polygenic risk, and children's impulsivity. | Elam KK et al. | — | 2017 | → |
| Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors. | Li JJ | — | 2017 | → |
| Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery. | Voss P et al. | — | 2017 | → |
| Environmental risks outweigh dopaminergic genetic risks for alcohol use and abuse from adolescence through early adulthood. | Coley RL et al. | — | 2017 | → |
| LP-211, a selective 5-HT<sub>7</sub> receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats. | Beaudet G et al. | — | 2017 | → |
| Polygenic Risk, Personality Dimensions, and Adolescent Alcohol Use Problems: A Longitudinal Study. | Li JJ et al. | — | 2017 | → |
| Symbolic Interactionism: A Framework for Understanding Risk-Taking Behaviors in Farm Communities. | Sorensen JA et al. | — | 2017 | → |
| The Grand Challenges for Evolutionary Psychology: Survival Challenges for a Discipline. | Jonason PK | — | 2017 | → |
| Attentional biases to emotional stimuli: Key components of the RDoC constructs of sustained threat and loss. | Gibb BE et al. | — | 2016 | → |
| More than Meets the Eye: Eye Color and Alcoholism. | Eissenberg JC | — | 2016 | → |
| Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict. | Elam KK et al. | — | 2016 | → |
| Striatal Dopamine, Externalizing Proneness, and Substance Abuse: Effects on Wanting and Learning during Reward-Based Decision Making. | Byrne KA et al. | — | 2016 | → |
| Blunted neural responses to monetary risk in high sensation seekers. | Zheng Y et al. | — | 2015 | → |
| Childhood Sexual Abuse and Impulsive Personality Traits: Mixed Evidence for Moderation by <i>DRD4</i> Genotype. | Harden KP et al. | — | 2015 | → |
| Sensation-seeking: Dopaminergic modulation and risk for psychopathology. | Norbury A et al. | — | 2015 | → |
| Sibling genes as environment: Sibling dopamine genotypes and adolescent health support frequency dependent selection. | Rauscher E et al. | — | 2015 | → |
| A brief history of research on the genetics of alcohol and other drug use disorders. | Schuckit MA | — | 2014 | → |
| Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. | Archer NP et al. | — | 2014 | → |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | — | 2014 | → |
| Variants in the dopamine-4-receptor gene promoter are not associated with sensation seeking in skiers. | Thomson CJ et al. | — | 2014 | → |
| Ventral striatal dopamine synthesis capacity is associated with individual differences in behavioral disinhibition. | Lawrence AD et al. | — | 2014 | → |
| A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology. | Bogdan R et al. | — | 2013 | → |
| Are there reciprocal relationships between substance use risk personality profiles and alcohol or tobacco use in early adolescence? | Malmberg M et al. | — | 2013 | → |
| Dopamine modulates risk-taking as a function of baseline sensation-seeking trait. | Norbury A et al. | — | 2013 | → |
| Integrating behavioral economics and behavioral genetics: delayed reward discounting as an endophenotype for addictive disorders. | MacKillop J | — | 2013 | → |
| Pitfalls of predicting complex traits from SNPs. | Wray NR et al. | — | 2013 | → |
| Sensation-seeking genes and physical activity in youth. | Wilkinson AV et al. | — | 2013 | → |
| Sensation seeking in major depressive patients: relationship to sub-threshold bipolarity and cyclothymic temperament. | Fornaro M et al. | — | 2013 | → |
| Toward an integration of cognitive and genetic models of risk for depression. | Gibb BE et al. | — | 2013 | → |
| Ventral striatal dopamine synthesis capacity predicts financial extravagance in Parkinson's disease. | Lawrence AD et al. | — | 2013 | → |
| Fetal programming of body composition, obesity, and metabolic function: the role of intrauterine stress and stress biology. | Entringer S et al. | — | 2012 | → |
| Genetically influenced change in sensation seeking drives the rise of delinquent behavior during adolescence. | Harden KP et al. | — | 2012 | → |
| Genetic variations in the dopaminergic system and alcohol use: a system-level analysis. | Chen C et al. | — | 2012 | → |
| Genetic variations in the dopamine system and facial expression recognition in healthy chinese college students. | Zhu B et al. | — | 2012 | → |
| Individual differences in cognition, affect, and performance: behavioral, neuroimaging, and molecular genetic approaches. | Parasuraman R et al. | — | 2012 | → |
| Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems. | Bell RL et al. | — | 2012 | → |
| Sensation seeking predicts brain responses in the old-new task: converging multimodal neuroimaging evidence. | Lawson AL et al. | — | 2012 | → |
| Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner. | Stoltenberg SF et al. | — | 2012 | → |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | — | 2012 | → |
| Adolescent sexual activity and the development of delinquent behavior: the role of relationship context. | Harden KP et al. | — | 2011 | → |
| Contributions of dopamine-related genes and environmental factors to highly sensitive personality: a multi-step neuronal system-level approach. | Chen C et al. | — | 2011 | → |
| Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. | Chen YC et al. | — | 2011 | → |
| Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. | Nikolova YS et al. | — | 2011 | → |
| Personality Measurement and Assessment in Large Panel Surveys* | Roberts B et al. | — | 2011 | → |
| Predicting sensation seeking from dopamine genes: use and misuse of genetic prediction. | Powell JE et al. | — | 2011 | → |
| The contribution of maternal stress to preterm birth: issues and considerations. | Wadhwa PD et al. | — | 2011 | → |