Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait.
paper
Cited
Public
Unavailable
- Authors
- Lang, Undine E; Bajbouj, Malek; Sander, Thomas; Gallinat, Juergen
- Year
- 2007
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 17299513
- DOI
- 10.1038/sj.npp.1301335
The gene encoding cathechol-O-methyltransferase (COMT) contains a common functional missense polymorphism (Val158Met) that regulates dopamine in an allele-dependent manner. A pivotal role of dopamine neurotransmission in the prefrontal cortex has been implicated in drug-seeking behavior and related personality traits, such as sensation seeking, with some evidence for a gender-specific association. Here, we tested the hypothesis that the COMT Val158Met polymorphism modulates the personality dimension, sensation seeking, in a gender-dependent manner. Study sample included 214 male (age 38.1+/-12.6 years) and 218 female (age 36.1+/-13.6 years) healthy volunteers, who were assessed with Zuckerman's sensation-seeking scale and genotyped for the Val158Met polymorphism (dbSNP:rs4680). Univariate analysis of variance showed that the sensation seeking score was significantly affected by a COMT genotype x gender interaction (F=5.330, df=2, p=0.005). The Val158Met polymorphism was associated with the sensation seeking personality trait in women only. The highest scores in the sensation-seeking scale and in three of the four subscales were observed in female subjects with the Val/Val genotype relative to women carrying the Met allele. Our results suggest that high COMT enzyme activity associated with the Val allele predisposes to high sensation seeking scores in female subjects and add to increasing evidence for a gender specific role of COMT in normal and dysfunctional behavior.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Predicting sensation seeking from dopamine genes. A candidate-system approach. | 2010 | 20732903 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Dimensional Affective Sensitivity to Hormones across the Menstrual Cycle (DASH-MC): A transdiagnostic framework for ovarian steroid influences on psychopathology. | Peters JR et al. | — | 2025 | → |
| Neural indices of heritable impulsivity: Impact of the COMT Val158Met polymorphism on frontal beta power during early motor preparation. | Happer JP et al. | — | 2024 | → |
| Association of Internet gaming disorder with catechol-O-methyltransferase: Role of impulsivity and fun-seeking. | Yen JY et al. | — | 2022 | → |
| Appetite effects of prefrontal stimulation depend on COMT Val158Met polymorphism: A randomized clinical trial. | Fassini PG et al. | — | 2019 | → |
| Haplotypic and Genotypic Association of Catechol-<i>O</i>-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia. | Sagud M et al. | — | 2018 | → |
| The COMT Val158Met Polymorphism and Reaction to a Transgression: Findings of Genetic Associations in Both Chinese and German Samples. | Sindermann C et al. | — | 2018 | → |
| Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder. | Vai B et al. | — | 2017 | → |
| COMT Val<sup>158</sup>Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function. | Elton A et al. | — | 2017 | → |
| A Dopamine Pathway Gene Risk Score for Cognitive Recovery Following Traumatic Brain Injury: Methodological Considerations, Preliminary Findings, and Interactions With Sex. | Myrga JM et al. | — | 2016 | → |
| Novelty Seeking, Harm Avoidance, and Cerebral Responses to Conflict Anticipation: An Exploratory Study. | Hu J et al. | — | 2016 | → |
| Analysis of the Association between Catechol-O-Methyltransferase Val158Met and Male Sexual Orientation. | Yu W et al. | — | 2015 | → |
| COMT-by-sex interaction effect on psychosis proneness. | de Castro-Catala M et al. | — | 2015 | → |
| Is the experience of thermal pain genetics dependent? | Horjales-Araujo E et al. | — | 2015 | → |
| Ovarian hormones and borderline personality disorder features: Preliminary evidence for interactive effects of estradiol and progesterone. | Eisenlohr-Moul TA et al. | — | 2015 | → |
| The mediating effect of prefrontal asymmetry on the relationship between the COMT Val(158)Met SNP and trait consummatory positive affect. | Katz AC et al. | — | 2015 | → |
| Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis. | Lee LO et al. | — | 2014 | → |
| Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. | van der Knaap LJ et al. | — | 2014 | → |
| Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers. | Gibbs AA et al. | — | 2014 | → |
| Gender-specific association between the COMT Val158Met polymorphism and openness to experience in panic disorder patients. | Konishi Y et al. | — | 2014 | → |
| Ovarian cycle effects on immediate reward selection bias in humans: a role for estradiol. | Smith CT et al. | — | 2014 | → |
| Catechol-O-methyltransferase Val158Met polymorphism modulates gray matter volume and functional connectivity of the default mode network. | Tian T et al. | — | 2013 | → |
| Effect of COMT Val158Met polymorphism on personality traits and educational attainment in a longitudinal population representative study. | Lehto K et al. | — | 2013 | → |
| Effects of acute dopamine precusor depletion on immediate reward selection bias and working memory depend on catechol-O-methyltransferase genotype. | Kelm MK et al. | — | 2013 | → |
| Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. | Mutschler J et al. | — | 2013 | → |
| The interaction between Comt and Bdnf variants influences obsessive-compulsive-related dysfunctional beliefs. | Alonso P et al. | — | 2013 | → |
| Children under stress - COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm. | Armbruster D et al. | — | 2012 | → |
| Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-Spectrum Disorders. | Groleau P et al. | — | 2012 | → |
| Genetically influenced change in sensation seeking drives the rise of delinquent behavior during adolescence. | Harden KP et al. | — | 2012 | → |
| The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex. | Amstadter AB et al. | — | 2012 | → |
| Genetically determined dopamine availability predicts disposition for depression. | Felten A et al. | — | 2011 | → |
| Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders. | Tunbridge EM et al. | — | 2011 | → |
| Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability. | Bhowmik AD et al. | — | 2011 | → |
| Sex modulates the associations between the COMT gene and personality traits. | Chen C et al. | — | 2011 | → |
| The canary in the coalmine: the sensitivity of mesolimbic dopamine to environmental adversity during development. | Gatzke-Kopp LM | — | 2011 | → |
| Variation in genes involved in dopamine clearance influence the startle response in older adults. | Armbruster D et al. | — | 2011 | → |
| Association analysis between 12 genetic variants of ten genes and personality traits in a young chinese Han population. | Gong P et al. | — | 2010 | → |
| Aversive stimuli lead to differential amygdala activation and connectivity patterns depending on catechol-O-methyltransferase Val158Met genotype. | Rasch B et al. | — | 2010 | → |
| Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. | Segall SK et al. | — | 2010 | → |
| Genetic aspects of the Paget's disease of bone: concerns on the introduction of DNA-based tests in the clinical practice. Advantages and disadvantages of its application. | Falchetti A et al. | — | 2010 | → |
| Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. | Mier D et al. | — | 2010 | → |
| Predicting sensation seeking from dopamine genes. A candidate-system approach. | Derringer J et al. | — | 2010 | → |
| The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. | Mukherjee N et al. | — | 2010 | → |
| The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness. | Salo J et al. | — | 2010 | → |
| Catechol O-methyltransferase (COMT) VAL158MET functional polymorphism, dental mercury exposure, and self-reported symptoms and mood. | Heyer NJ et al. | — | 2009 | → |
| Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. | Roe BE et al. | — | 2009 | → |
| Genes, cognition and brain through a COMT lens. | Dickinson D et al. | — | 2009 | → |
| Musical aptitude is associated with AVPR1A-haplotypes. | Ukkola LT et al. | — | 2009 | → |
| Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation. | Schmack K et al. | — | 2008 | → |
| Genes and neuroimaging: advances in psychiatric research. | Gallinat J et al. | — | 2008 | → |
| Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with personality traits in healthy individuals. | Krug A et al. | — | 2008 | → |
| Sex steroid-related candidate genes in psychiatric disorders. | Westberg L et al. | — | 2008 | → |