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Chunk #17 — Materials and Methods — Smoking-related diseases — Chronic obstructive pulmonary disease

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A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences.
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Denmark Participants in a LC screening study of 4104 current or previous smokers (2004–2006),27 708 were diagnosed with COPD based on sprirometry (FEV1/FVC<0.7) and emphysema based on high resolution computed tomography scan.