The interaction of naltrexone with OPRM1 genotype on subject drinking under normal environmental conditions during the five days prior to experimental procedures was not significantly different either for drinks per day or percent heavy drinking days (table 2). There were no significant main effects of OPRM1 genotype (F(1,81)=0.70, p=0.40) or medication (F(1,81)=2.15, p=.15) on drinks per day and no significant main effects of OPRM1 genotype (F(1,81)=.32, p=0.57) or medication (F(1,81)=.545, p=.46) on percent heavy drinking days. Adding covariates of age, ADS score, or baseline drinking did not substantially alter the findings. Sex did not have an effect on this analysis.
