There is interest in drugs with the potential to block or reverse some of the damage caused by binge drinking. Our upstream regulator analysis (Supplemental Tables 2, 3) suggests that Mifepristone and fulvestrant (an estrogen receptor antagonist) might reverse some of the effects of alcohol in all 4 brain regions (see also McClintick et al., 2015, 2016). In the hypothalamus, ethanol has the same effects as estrogen (Sarkar & Boyadjieva, 2007). Most other drugs identified by upstream analysis show differences among the 4 brain regions.
