risk across those with elevated genetic risk, clinical/environmental risk, and both. Those in the top 10% of both PGS and CERI had the highest prevalence of each of the SUDs, though the error bars overlap with the estimates from those in the top 10% of the risk index, alone. Compared to those in the bottom 90% on both, those in the to the top 10% of both have a relative risk of 3.86 (95% CI = 3.20, 4.65) for alcohol dependence, 6.11 (95% CI = 4.84, 7.72) for nicotine dependence, 8.04 (95% CI = 6.92, 9.36) for drug dependence, and 4.05 (95% CI = 3.64, 4.51) for any substance dependence.
