Figure 1A presents the raw prevalence for each outcome across counts of the CERI. The proportion of those meeting criteria for SUDs among those reporting 3 or more, 5 or more, and 7 or more risk factors surpassed lifetime prevalence estimates from nationally representative samples for drug dependence, alcohol dependence, and nicotine dependence, respectively [58]. Panel B depicts the prevalence of each category of SUD across several mutually exclusive categories: (1) those in the bottom 90% of both the CERI and all PGS (averaged across the six scores); (2) those in the top 10% of the CERI but the bottom 90% of the PGS distribution; (3) those in the top 10% of the PGS distribution and the bottom 90% of the CERI; and (4) those in the top 10% of both PGS and the CERI. There is an increase in risk across those with elevated genetic risk, clinical/environmental risk, and both. Those in the top 10% of both PGS and CERI had the highest prevalence of each of the SUDs, though the error bars overlap with the estimates from those
