RPS26 gene on chromosome 12q13.2, within 500 KB of three GWAS SNPs associated with Type 1 diabetes (False discovery rate (FDR) corrected P < 1.45 × 10− 38 for association with rs11171739 in the frontal cortex, P < 6.72 × 10− 51 in cerebellum and P < 9.46 × 10− 67 in blood) (Barrett et al., 2009, 2007; Cooper et al., 2008, Hakonarson et al., 2008, Todd et al., 2007). Additional significant SNP:probe pairs found in both datasets included SNPs associated with traits such as mean corpuscular volume (Ganesh et al., 2009) , smoking behavior (2010), eye color (Liu et al., 2010b), plasma levels of liver enzymes(Yuan et al., 2008) and inflammatory bowel disease (Kugathasan et al., 2008) (Supplementary Table 1). For fifteen SNP:probe associations that were significant in brain and blood, the direction of effect was consistent across all three tissues.
