A divergent set of eQTLs were found in the blood dataset when compared with cerebellum and frontal cortex (Figs. 3A,B). Several of these eQTLs were for probe ILMN_1666206, which maps to the GSDML gene on Chr17q12. These correlations are linked with five separate GWA studies associating Type 1 diabetes (2007; Barrett et al., 2009, Cooper et al., 2008, Hakonarson et al., 2008, Todd et al., 2007), Crohn's disease (Barrett et al., 2008) and Ulcerative colitis (McGovern et al., 2010) to the same locus (Supplementary Table 1). Additionally, the ILMN_1666206 probe has been nominated as underlying an eQTL in studies of asthma and white blood cell traits associated with a pro-inflammatory state (Moffatt et al., 2007, Nalls et al., 2011a). The FDR corrected P value for the most significantly associated SNP, rs2290400, with this probe was 6.41 × 10− 32 in blood but 0.924 and 0.896 in the cerebellum and frontal cortex respectively.
