From its inception, JASPAR provided a web interface catering to the needs of both wet and dry researchers, illustrating JASPAR’s emphasis on ‘ease of use.’ This principle translates into design choices for the JASPAR database, starting with the data organised in a simple schema trying to make one profile correspond to one TF or one dimeric complex (e.g. MYC::MAX) in one taxon, corresponding to the non-redundant aspect of JASPAR. However, this condition was later relaxed in 2020 to introduce binding variants (13), reflecting the possibility for some TFs to bind two or more distinct DNA motifs. This simple architecture makes JASPAR easy to engage for any user. We further provide different interfaces ranging from straightforward web-interface to programmatic access through various packages in Perl (16), Python (17), R/Bioconductor (18), and Ruby (12). Further catering to the community's needs, access to JASPAR data has been expanded to incorporate a platform- and language-independent interface through the recent introduction of the JASPAR RESTful API (19). JASPAR’s ease of use was further facilitated by introducing the new web-interface and including the ‘JASPAR dynamic tour’ in 2018, which guides users through the typical tasks and novel features of the JASPAR website (20).
