The team behind JASPAR has continuously tried to encompass the current scope of the data produced in the field. Of note in this effort is the rapid expansion witnessed following the introduction of high-throughput sequencing assays such as ChIP-seq (21), DAP-seq (22), PBM (23), SMiLE-seq (24), and HT-SELEX (25), which accelerated the generation of datasets suitable for modelling TF-DNA interactions (26,27). This process, which started with vertebrates, eventually reached all taxa present in JASPAR. Faced with this expansion, we adapted the procedures and pipelines at the source of JASPAR, moving from the original manual survey of journals and subsequent construction of profiles directly from article tables or images to a systematic motif processing pipeline from online resources. This process was also fueled by the integration of data from ReMap (28), GTRD (29), and CIS-BP (4) directly into our pipelines, illustrating the merit of such open science efforts in consolidating the field as a whole again. Furthermore, the increasing number of profiles inferred across numerous taxa allowed new functionalities, such as interactive profile clustering trees (20) or archetypes (9), to assist users in interpreting individual profiles within a broader context.
