Here, we present the 10th release of the JASPAR database, providing a substantial update and expansion of TF binding profiles in seven taxonomic groups. This update includes the addition of 329 profiles as PFMs, orthogonal support for 72 profiles stored in the previous release's UNVALIDATED collection (i.e. they are now part of the CORE collection), an update of three profiles and an update of the metadata for 241 profiles. Moreover, 182 new PFMs were added to the UNVALIDATED collection. This release further includes updates to the word clouds displaying enriched terms associated with TFs in the literature, further improvement of the structural classification of plant TF DBDs, updated native UCSC human and mouse genome tracks with TFBSs predicted from JASPAR TF binding profiles, and updates on the various JASPAR tools such as the TFBS enrichment tool, pyJASPAR and R/Bioconductor packages. We introduce a new motif trimming algorithm to remove flanking positions from PFMs with low information content. Finally, we provide a new TFBS extraction tool to perform extraction of predicted JASPAR TFBSs intersecting with an input set of genomic regions provided by users.
