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Chunk #50 — Materials and Methods — There were three phases to this study — EEG Analysis

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Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP.
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For the purposes of deletion of drowsiness or sleep a temporary data file was first constructed for each EEG record using a digital, finite-impulse response, bandpass filter with cutoffs at 2.5 to 30 Hz. A computer monitor displayed consecutive 5 sec intervals of EEG waveforms with gridlines at 1 sec intervals. All three minutes of eyes-closed EEG was scanned in this way and epochs containing artifacts, drowsiness or sleep were deleted. Almost all subjects showed 100 sec or more of acceptable EEG recordings. The minimum was twenty five 2.56 sec epochs. Data from acceptable epochs was averaged to yield a composite spectrum spanning three frequency domains: 3–8 Hz, 8–13 Hz and 13–30 Hz. We excluded the delta band because of the likelihood of large measurement error due, for example, to residual eye movement artifacts as has been found in other studies [17]. The absolute spectral power in each of the three frequency bands at each of the six electrode locations was log transformed to normalize the distribution. The EEG data from 9 participants was excluded because of poor quality and therefore the EEG dataset comprised 364 individuals.