We estimated polygenic scores (PGS), which are aggregate measures of the number of risk alleles individuals carry weighted by effect sizes from GWAS summary statistics, for a variety of psychiatric and substance use phenotypes. We included PGS derived from recent GWAS of (1) alcohol use disorders (AUD) [43], (2) depression (DEP, 23andMe excluded) [44], (3) post-traumatic stress disorder (PTSD) [45], (4) bipolar disorders (BIP) [46, 47], (5) schizophrenia (SCZ) [47, 48] (6) smoking initiation (SMOK, as a proxy for externalizing risk) [49, 50] and (7) suicide attempt (SUI) [19]. For AUD and BIP, we meta-analyzed published GWAS results with corresponding results from FinnGen (release 9, see supplemental information for results) [51]. We focus on these PGS specifically because: 1) these disorders are phenotypically correlated with suicide attempt, and 2) they contain GWAS results for both European and African ancestries. For GWAS that originally included COGA in the discovery sample, we obtained summary statistics with COGA removed.
