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Chunk #34 — Discussion

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Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study.
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In considering the SNPs in high LD and comparing results to previous reports, our findings are in agreement with Dick (2006) and Sakai (2010) in not finding an association with adolescent AAD and rs279871 or rs279858 in GABRA2, yet our results contrast with theirs in findings with CD. In the GADD sample, rs9291283 was associated with CD in adolescence/young adulthood (p = 0.005). This result was not seen in the CADD sample, or in the combined CADD and GADD sample. This may be due in part to the finding that, for CD, the G allele was over-transmitted to affected offspring in the CADD sample. Although this finding was not significant, it could explain why, when the two samples were combined, rs9291283 was not associated with CD despite the fact it was the strongest association in the study. In the Dick (2006) and Sakai (2010) studies, rs279871 was found to be associated with adolescent CD, yet here neither rs279871 nor the SNP we examined in high LD (r2 > 0.8) with this SNP, rs279858, was associated with CD. Interestingly, the Sakai