a proliferation of illicit use of novel amphetamine analogues, including methcathinone and methylenedioxymethcathinone, among others. These compounds differ from other amphetamine-like compounds in their subjective effects, their potential for adverse effects and their selectivity for various monoamine transporters (Martinez-Clemente, Escubedo, Pubill, & Camarasa, 2012; Schifano, et al., 2011). Because amphetamine-like compounds have diverse effects, potentially determined by multiple monoamine transporters in addition to VMAT2, KO studies have been used in an attempt to determine which monoamine systems are critical components of the actions of different amphetamine analogues.
