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Chunk #24 — Discussion

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The possible influence of impulsivity and dietary restraint on associations between serotonin genes and binge eating.
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It may be that different types of impulsivity and/or BN symptoms show interactive relationships. For example, different types of impulsivity (e.g., the BIS-11 subscales of Attentional, Motor, and Non-planning Impulsiveness) may more strongly moderate gene/binge eating relationships than the BIS-11 Total Score, as these subscales have been found to be differentially associated with eating disorder syndromes and symptoms (Rosval et al., 2006). In addition, other symptoms of BN (e.g., weight preoccupation, body dissatisfaction) may be more likely to show significant interactive associations. Post-hoc analyses were conducted to examine these possibilities. However, we found that the BIS-11 subscales (see above) did not significantly moderate gene/binge eating relationships, and interaction effects were not significant for the MEBS Total Score, Weight Preoccupation, and Body Dissatisfaction subscales (data not shown). Nevertheless, we cannot rule out the possibility that other aspects of impulsivity (e.g., borderline traits; (Nishiguchi et al., 2001); urgency (Fischer et al., 2003)) and other BN symptoms are involved in moderating relationships.