All smart-pool siRNAs and GIPZ lentivirus shRNAmir were purchased from Dharmacon and Open Biosystems, respectively. LPS E. coli 0111:B4 used at 0.1 μg/ml final, SB216763 as indicated, and Cycloheximide used at 10 μg/ml final were obtained from Sigma. Human and mouse IL1β used at10 ng/ml final and TNFα used at 50 ng/ml final were from R&D system.