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Chunk #19 — Discussion

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A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study.
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studies in AA were relatively small and showed mixed results that were mainly not replicated in our study. As the number of variants genotyped in any AA study was limited (10 to 50 SNPs), we were able to investigate if genotyping or imputing additional variants in this region (in total 3,756) may even further reduce the list of possible functional variants and search for second independent signal(s).