was not replicated by the current study. In two fine-mapping studies [5], [14], no FTO-BMI associations were noted, possibly because the majority of subjects were lean (∼75% had a BMI between 18–25) in one study [14], or because the sample size was small in both studies (about 1,100). Hassanein et al. [31] genotyped 34 tagging SNPs in the FTO intron 1 region in 4,217 AA and followed up findings from two variants (rs3751812, p-value = 4×10−4 and rs9941349, p-value = 6×10−5) in four additional studies (n = 5,664), adding some support (p-values ranging from 0.016 to 0.64) which resulted in overall p-values of 2.6×10−6 and 3.6×10−6, respectively. The authors concluded that this finding reduced the potential functional variants to those correlated with these two variants. Both variants (rs3751812 and rs9941349) were also associated in our meta-analysis (p-value 0.001 and 0.005, respectively; Table S4), although they were not among the most significant findings. In summary, except for Hassanein et al. [31], studies in AA were relatively small and showed mixed results that were mainly not replicated in our study. As the number of variants genotyped in any AA study was limited (10 to 50 SNPs), we were able to investigate if
