To conduct a more comprehensive evaluation of the FTO locus, some AA studies extended the SNPs list from the EA index SNPs described above (Table S4). Grant et al. [27] analyzed eleven FTO SNPs genotyped as part of their GWAS in about 2,000 AA children and only rs3751812 showed a marginally significant association with BMI (p-value = 0.02). Wing et al. [18], [19] genotyped up to 27 SNPs in the intron 1 of FTO in a cohort study and family study including 288 and 604 AA, respectively, and observed an association of BMI with rs1108102 (p-value = 5×10−4; [18]); however, this finding was not confirmed in their cohort study or in our larger meta-analysis (Table S4). A fine mapping study of 47 tagging SNPs in 497 AA children [28] identified an association of rs8057044 (p-value = 5×10−4) with BMI, which was not replicated by the current study. In two fine-mapping studies [5], [14], no FTO-BMI associations were noted, possibly because the majority of subjects were lean (∼75% had a BMI between 18–25) in one study [14], or because the sample
