in mean methylation. Among the two studies by the same group using the custom array, positive associations with HTR3A were found in one study, though in European Americans only [95], and in the other, no associations with alcohol use alone were found, but there appeared to be an effect of childhood adversity on methylation at two loci (CHRNA5, HTR1B) in the combined alcoholic and non-alcoholic European American sample [96].
