Representative gene modules were examined for group-wise overrepresentation of genetic variants within the database of genotypes and phenotypes (dbGaP) 29 for the public results of two alcohol dependent studies and three non-psychiatric diseases as negative controls: Collaborative Study on the Genetics of Alcoholism (phs000125.v1.p1), Study of Addiction: Genetics and Environment (phs000092.v1.p1), National Eye Institute Age-Related Eye Disease Study for age-related macular degeneration and cataracts (phs000001.v3.p1), NIDDK IBD Genetics Consortium Crohn’s Disease (phs000130.v1.p1), and Type 1 Diabetes Genetics Consortium (phs000180.v2.p2). Individual datasets were extracted from dbGaP, filtered for genetic variants with P-values ≤ 0.01, and annotated for associated gene identifiers 30.
