Chunk #21 — BACKGROUND — First findings of ENIGMA‐OCD: Cortical thickness, surface area and subcortical volume

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An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.

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Analyses of alterations in brain asymmetry, in partnership with ENIGMA's Laterality working group, showed that children/adolescents with OCD (n = 501) versus healthy controls (n = 439) have altered asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and pallidum (less leftward, Cohen's d = −0.21), which was not detectable in adult OCD, possibly reflecting altered neurodevelopmental processes (Kong et al., 2019; Figure 2).