The fast potassium currents were ~ 8% increased in LR compared with control neurons (0 = 0.014, two-way analysis of variance) and ~ 5% increased in LR neurons compared with NR neurons (P = 0.0085) (Figure 3c). The slow potassium currents did not change between the three groups (Figure 3d). The sodium-to-potassium ratio was 42% reduced in NR neurons compared with control (P = 0.0002) and LR neurons (P = 0.0006) (Figure 3e). Capacitance was slightly increased in LR neurons, but a significant difference was seen in NR neurons (P = 0.038) (Figure 3f). Cell input conductance did not change between the three groups (Figure 3g). Spike shape differed between the three groups: LR neurons had a higher spike amplitude (+17% P = 0.0002), whereas NR had a smaller spike amplitude compared with controls (−13%, P = 0.01) (Figure 3h). As noted in the previous section, the combination of channels that have stronger currents at −40 mV (86% increase in LR neurons compared with controls, P = 0.02) and a faster kinetics gave rise to a bigger amplitude spike. If we look at the area under the curve of the sodium currents from −60 to −20 mV, it is increased
