mediator of TGF-β signaling and this pathway is known to modulate RNA processing via Smad protein interaction with RNA binding sites on miRNA (Davis et al., 2008). Thus, CLIC4 might regulate TGF-β/Smad-mediated modulation of RNA processing and therefore protein expression, which could ultimately influence neuronal responses to ethanol. While such a role for CLIC proteins in modulating ethanol-related behavior is speculative at this time, our approach of using multiple model organisms will allow us to investigate this and other possible mechanisms of CLIC proteins in behavioral responses to ethanol.
