In addition to the relationship of treatment-regulated genes within a single region, we were interested in the relationship of treatment-regulated genes between regions (Figure S3). The degree of overlap was greater than expected by chance between the amygdala and PFC for all three treatments (hypergeometric p < 0.05), suggesting that PPAR agonists differentially regulate genes in the brain versus the liver. Forty-one genes were regulated by both feno and tesa in both brain areas, including many genes involved in synaptic transmission (e.g., Nell2, Ppp2r5d, Rasgrf1, Syt1, Syn3, B3gat1, Sv2b, Sh3kbp1, Crhbp and Cldn5).
