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Chunk #25 — 3. Results — 3.3 Detailed gene expression analysis after PPAR agonist treatment

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PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption.
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The 424 genes regulated by feno and tesa in the amygdala are enriched for genes involved in synaptic transmission (e.g., Gabrg1, Abat and Bdnf) and dopaminergic synaptic transmission (e.g., Pmch, Drd1a, Ddc, Ppp1r1b and Crhbp). There was also an up-regulation of genes involved in anxiety-related responses (e.g., Npy, Tac1, Pdyn, Drd1a, Pde1b and Grm8).