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Chunk #24 — 3. Results — 3.3 Detailed gene expression analysis after PPAR agonist treatment

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PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption.
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We used the non-effective treatment as a filter to identify genes that were differentially expressed after feno and tesa but not beza treatment. There were 424 genes in this category in the amygdala and 467 in the PFC, and Table 2 highlights the top 20 up- and down-regulated genes in these key gene-sets. In general, if a transcript was changed by both feno and tesa, the change was in the same direction, especially in the amygdala.