or were not within the targeted age range for the study (25–44 years). Among the 5,010 individuals meeting eligibility requirements, 3,137 were interviewed (response rate = 63%), and 2,949 donated a blood sample for genetic testing (response rate = 94%). The initial wave of genotyping was limited to European-Americans ascertained prior to summer 2005, who comprise the 789 cases and 811 controls analyzed here. Procedures were approved by Institutional Review Boards of participating institutions, and were carried out in accord with the Helsinki Declaration.
