The purpose of this review was to identify the environmental and psychological triggers that may cause disinhibition to fluctuate, and outline the implications of these fluctuations for the understanding and treatment of substance use disorders. The focus on state disinhibition is timely, because theoretical models now acknowledge that disinhibition is unlikely to function as a fixed and stable trait. Instead, temporary fluctuations in disinhibition may also contribute to substance use (2). The research reviewed in this paper lends support to this idea.