Chunk #18 — RESULTS — In parallel, dietary zinc supplementation in vivo improved both PU.1 and Nrf2 nuclear binding in alveolar macrophages from alcohol-fed rats

Source

Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats.

Embedded

yes

Text

We next extended these findings of zinc treatment in vitro on PU.1 and Nrf2 nuclear binding in alveolar macrophages from alcohol-fed rats. As dietary zinc supplementation preserved lung bacterial clearance in alcohol-fed rats in vivo, we reasoned that PU.1 and/or Nrf2 nuclear binding should also be increased in the alveolar macrophage in vivo if activation of GM-CSF signaling and/or the ARE were a plausible explanation for the efficacy of zinc supplementation.