Chunk #11 — Results — Transcript levels in GAD67 heterozygous mice

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Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia.

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Grain counting analyses (Figure 3A) revealed a similar effect of reduced GAD67 expression on cellular CB1R mRNA levels. The mean number of CB1R grains per neuron was 12% lower (t10=1.79, p=0.08) in GAD67+/− mice (40.8 ± 5.1) relative to WT mice (36.0 ± 3.7) (Figure 3B).