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Chunk #56 — Figure 5

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Efficient derivation of microglia-like cells from human pluripotent stem cells.
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pMGLs recapitulate the consensus signature distinguishing primary microglia from other macrophages(a) Quantification of normalized expression (counts from RNAseq data) of the indicated genes for pMGLs (black bars, N=5), primary human fetal microglia (red bars, hFMG, N=2), and differentiated human neural progenitors (red bars, Diff. NPCs, N=4). Data are presented as mean ± s.e.m. (b) Dendrogram depicting the results of unbiased hierarchical clustering of fMGs (N=2), pMGLs (N=5) and NPCs (N=4) derived in this study, compared to a published dataset (GSE73721) 31 for adult primary microglia (N=3), fetal astrocytes (N=6), mature astrocytes (N=12), neurons (N=1) and whole cortex (N=4), using genes in Suppl. Table 8.