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Chunk #49 — Discussion — Limitations

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Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2.
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and hassles were reported for the past week, improving accuracy of recall but introducing uncertainty about the degree to which the past week was typical of respondents’ experiences. For these reasons, the GxExE effect reported may be difficult to replicate without a large sample and more precise measurement over longer periods of time. Finally, the extent to which the GxE effect demonstrated in men is consistent with theories of social control and behavioral disinhibition cannot be adequately tested with the COGA data. Thus, future research should systematically explore associations between family and employment characteristics, feelings of social integration and life satisfaction, identity, and alcohol use.