This study provides an additional step towards understanding the genetic architecture of ASD. We show a robust relationship with the genetic risk identified in schizophrenia GWAS and have highlighted loci such as 10q24.32 and gene-sets that have been previously and independently implicated in ASD and related disorders. Shared heritability findings and our cross-disorder meta-analysis reveals additional GWS loci that may be important in neurodevelopment including a region flagged as a neurodevelopmental hub on chromosome 8p as well as the ATP2B2 gene located at 3p25.3, a gene previously implicated in ASD through both genetic association [61–63] and differential expression in the post-mortem brain tissues of individuals with ASD [64].
