The consistent pattern of thinner cortex observed across disorders may be associated with a common psychopathology dimension that has been described across clinical symptoms [52]. The transdiagnostic pattern of anatomical abnormalities may, in turn, be linked to shared underlying neurobiological factors [11–15]. Previous studies have revealed the pathological roles of voltage-gated potassium channels in various psychiatric, neurodegenerative disorders and substance use disorders [14, 53–56]. For example, some potassium channel genes have been considered candidate markers for SCZ and BD [54, 56], and it has been shown that loci within the KCN family genes (i.e., KCNB2) are pleiotropic to several psychiatric disorders [14]. Studies have shown the fundamental roles of potassium channels in mechanisms of neural plasticity [56–58], which may explain their relevance with morphological abnormalities in psychiatric disorders.
