WTCCC data contributed to identification of two additional robustly replicating T2D signals, mapping to the 1GF2BP2 gene and CDKN2A/CDKN2B regions19,21,22, although neither generated impressive P values on the primary scan analysis (neither single-point P was <10-4). The latter signal maps to the same region as the CAD signal on chromosome 9 though different SNPs are involved. The other SNPs in Table 4 do not map to genes or regions previously implicated in T2D pathogenesis, and replication efforts to date have not identified any confirmed signals19.
