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Chunk #47 — Review

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Genome-wide association studies in ADHD.
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(including 100 kb of flanking sequences) ranked according to the mean rank calculated across three statistics as reported by Lesch et al. (2008) for association with persistent ADHD in adultsSNPMean of ranksANOVA P valueLocusPhysical positionPositionGene functiona Additional remarksrs1124389715.63E-089q34.13134608104In intron of C9orf98 Encodes chromosome 9 open reading frame 98, a putative adenylate kinase-like protein of unknown function expressed in brain and other tissuesrs258769522.73E-072q14.2120038287In intron of PCDP1 = MGC33657 Encodes primary ciliary dyskinesia protein 1, a protein playing an important role in ciliary and flagellar biogenesis and motility of (among others) the cilia of respiratory epithelial cells and brain ependymal cells in both mice and humans. Finding lies within linkage region for schizophrenia from meta-analysis (Lewis et al. 2003)rs86464341.30E-083p22.239530584In 3′UTR/intron of MOBP Encodes myelin-associated oligodendrocyte basic protein. The gene shows altered expression in several areas of the brain of patients with substance use disorders (Albertson et al. 2004; Mitkus et al. 2008). Finding lies close to a linkage region for schizophrenia from meta-analysis (Lewis et al. 2003)Also lies within suggestive linkage region for ADHD reported in the same publication (Lesch et al. 2008)rs2199161111.62E-065q13.271446112In intron of MAP1B Encodes microtubule-associated protein 1B, a member of a protein family thought to be involved in microtubule