In the total sample of our AA replication cohort, these four SNPs did not achieve significant p values for association with SQ, HSI and FTND. However, in the male sub-group of our replication sample, the SNP rs17354547 was significantly associated with SQ, HSI and FTND, achieving p values of 0.031, 0.0046 and 0.019, respectively. In addition, a haplotype formed by the SNPs rs17354547, rs1402812 and rs4956396 was also associated with SQ, HSI and FTND, achieving p values of 0.039, 0.0093 and 0.0093, respectively. Since a total of four major haplotypes were tested, to adjust for multiple testing, the significance level for the haplotype association analysis was reset at 0.0125 through Bonferroni correction (0.05/4). Therefore, based on the adjusted significance level, the haplotype association was significant for only two ND phenotypes, which are HSI and FTND. Additional details for the above results are presented in Table 3.
