(Gelernter et al., 2014), and Maxdrinks (p = 2.5×10−10) (Xu et al., 2015). The most recent meta-analysis of African Americans (n = 6280) showed association of ADH1B*3 with AD (p = 2.2×10−9) (Walters et al., 2018). Many SNPs extending across most of the ADH region, from ADH1C to past ADH5, are in LD with rs2066702, and provided supporting evidence (Supplementary Figure 2).