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Chunk #9 — Introduction — Social Interaction

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Alcohol during adolescence selectively alters immediate and long-term behavior and neurochemistry.
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the passive social influence of social interaction with an alcohol-intoxicated peer on changes in behavior in the ethanol-naïve adolescent observer. Specifically, we assessed the impact of repeated pairings of social interaction with an alcohol-intoxicated peer paired with environmental cues on changes in preference for the chamber paired with social interaction with an alcohol-intoxicated peer in adolescent male and female rats. Our paradigm followed the same age and number of pairings of social interaction with an alcohol-intoxicated peer as that used in the Fernandez-Vidal and Molina (2004) study. In the present work, rats were given a 15-minute baseline conditioning assessment on PND 30 in which rats had free access to both chambers to assess baseline preferences for each chamber. The chamber the adolescent observer rat spent the least amount of time in was paired with social interaction with an alcohol-intoxicated peer. Control rats socially interacted with the same alcohol-free peer in both chambers. Conditioning occurred over a period of four days from PND 31–34. Specifically, in the morning, all rats underwent social isolation in a holding cage and water administration to the demonstrator after the initial 30 minutes of social isolation followed by an additional 30 minutes of social isolation. Rats